To build a prediction for the Italy - Spain match, scheduled for 6 October 2021, several key factors could influence the outcome. Italy have played 43 matches, in which they won 28 of them, drew 11 times and lost 4 matches. Spain, having played 44 matches, won 29 times, drew 9 matches and lost 6 defeats. In the league, Italy average 2 goals scored per game and 0.5 conceded. Spain average 2.7 scored and 0.8 conceded. These sides last met on 1 September 2017 at Spain's ground, where the home side came out on top.