Ath Bilbao, a team geared toward cup competitions, generally perform quite well in them, but the hosts have also found very good form and, most importantly, they are scoring. I can certainly see a blitz from Osasuna in the first half.
The referee shows 3+ YC per match on average; Everton has repeatedly shown that they can put up resistance against top clubs. I dare to assume that the majority of yellow cards will be shown in the 2nd half.